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Article

Emergence of X4 usage among HIV-1 subtype C: evidence for an evolving epidemic in South Africa.

AIDS (London, England) - 23 Apr 2008

Connell Bridgette J, Michler Katherine, Capovilla Alexio, Venter Willem D F, Stevens Wendy S, Papathanasopoulos Maria A

Abstract excerpt

This study investigated the genotype and phenotype of HIV-1 isolates of 20 South African AIDS patients. We found the highest percentage of CXCR4 usage among primary isolates, in which 30% efficiently utilized CXCR4 and exhibited the syncytium-inducing phenotype. Phylogenetic analysis of env confirmed that 19 of the 20 were subtype C, and syncytium-inducing viruses had genetic changes in the V3 loop,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18427209
DOI: 10.1097/QAD.0b013e3282f57f7a

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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