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Article

High frequency of syncytium-inducing and CXCR4-tropic viruses among human immunodeficiency virus type 1 subtype C-infected patients receiving antiretroviral treatment.

Journal of virology - 1 Jul 2003

Johnston Elizabeth R, Zijenah Lynn S, Mutetwa Solomon, Kantor Rami, Kittinunvorakoon Chonticha, Katzenstein David A

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) subtype C viruses have been found to almost exclusively use the chemokine receptor CCR5 as a coreceptor for entry, even in patients with advanced AIDS. We have characterized subtype C virus isolates from 28 patients from Harare, Zimbabwe, 20 of whom were receiving antiretroviral treatment. Virus from 10 of the treated patients induced syncytium formation (SI virus) when...

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Source

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Identifiers

PMID: 12805470
DOI: 10.1128/jvi.77.13.7682-7688.2003
PMCID: PMC164829

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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