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Article

Significant role for ladC in initiation of Legionella pneumophila infection.

Infection and immunity - 1 Jul 2008

Newton Hayley J, Sansom Fiona M, Dao Jenny, Cazalet Christel, Bruggemann Holger, Albert-Weissenberger Christiane, Buchrieser Carmen, Cianciotto Nicholas P, Hartland Elizabeth L

Abstract excerpt

Previously, we identified ladC in a cohort of genes that were present in Legionella pneumophila but absent in other Legionella species. Here we constructed a ladC mutant of L. pneumophila and assessed its ability to replicate in mammalian cell lines and Acanthamoeba castellanii. The ladC mutant was recovered in significantly lower numbers than wild-type L. pneumophila at early time points, which was reversed upon...

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Identifiers

PMID: 18426879
DOI: 10.1128/IAI.00209-08
PMCID: PMC2446704

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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