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Article

Host-Specific Adaptation of Legionella pneumophila to Single and Multiple Hosts.

Molecular biology and evolution - 30 Jul 2025

Moreno Anaísa B, Paranjape Kiran, Cederblom Martina, Kay Elisabeth, Dobre-Lereanu Christian, Andersson Dan I, Guy Lionel

Abstract excerpt

Legionella pneumophila is an endosymbiotic bacterial species able to infect and reproduce in various protist and human hosts. Upon entry into human lungs, they may infect lung macrophages, causing Legionnaires' disease (LD), an atypical pneumonia, using similar mechanisms as in their protozoan hosts, despite the 2 hosts being separated by a billion years of evolution. In this study, we used experimental evolution...

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Topics

Legionella pneumophila
Humans
Acanthamoeba castellanii
Host Specificity
Mutation
Legionnaires' Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

U937 Cells

Macrophages

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Identifiers

PMID: 40609045
DOI: 10.1093/molbev/msaf161
PMCID: PMC12308824

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