Article
BRAF mutations in papillary thyroid carcinoma and emerging targeted therapies (review).
Molecular medicine reports - 1 Oct 2012
Leonardi Giulia Costanza, Candido Saverio, Carbone Maurizio, Raiti Fabio, Colaianni Valeria, Garozzo Sebastiano, Cinà Diana, McCubrey James A, Libra Massimo
Abstract excerpt
Papillary thyroid carcinoma (PTC) is the most common histotype among the thyroid cancer types. Although PTC is a curable malignancy, many patients relapse after treatment. Thus, there is a need to identify novel factors involved in the pathogenesis of PTC that may be used as targets for new therapies. The MAPK pathway has been implicated in the pathogenesis of PTC....
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