Article
Progress in the pathogenesis and genetics of Parkinson's disease.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 27 Jun 2008
Mizuno Yoshikuni, Hattori Nobutaka, Kubo Shin-Ichiro, Sato Shigeto, Nishioka Kenya, Hatano Taku, Tomiyama Hiroyuki, Funayama Manabu, Machida Yutaka, Mochizuki Hideki
Abstract excerpt
Recent progresses in the pathogenesis of sporadic Parkinson's disease (PD) and genetics of familial PD are reviewed. There are common molecular events between sporadic and familial PD, particularly between sporadic PD and PARK1-linked PD due to alpha-synuclein (SNCA) mutations. In sporadic form, interaction of genetic predisposition and environmental factors is probably a primary event inducing mitochondrial...
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