Article
Role of MMP-3 and MMP-9 and their haplotypes in risk of bladder cancer in North Indian cohort.
Annals of surgical oncology - 1 Nov 2010
Srivastava Priyanka, Mandhani Anil, Kapoor Rakesh, Mittal Rama D
Abstract excerpt
PURPOSE: Matrix metalloproteinases (MMPs) play critical roles in cancer development and progression. Nonsynonymous single nucleotide polymorphisms (SNPs) in functional domain of MMP-3 and MMP-9 contribute appreciably to cancer predisposition and aggression. To test this proposition we examined whether six SNPs of the MMP-3 and MMP-9 genes are associated with risk of bladder cancer (BC) in a North Indian...
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