Article
Impact of matrix metalloproteinase-11 gene polymorphisms upon the development and progression of hepatocellular carcinoma.
International journal of medical sciences - 1 Jan 2018
Wang Bin, Hsu Chin-Jung, Lee Hsiang-Lin, Chou Chia-Hsuan, Su Chen-Ming, Yang Shun-Fa, Tang Chih-Hsin
Abstract excerpt
Hepatocellular carcinoma (HCC) is a liver malignancy and a major cause of cancer mortality worldwide. Matrix metalloproteinase-11 (MMP-11), also known as stromelysin-3, plays a critical role during tumor migration, invasion and metastasis. Here, we report on the association between five single nucleotide polymorphisms (SNPs) - rs738791, rs2267029, rs738792, rs28382575, and rs131451 - of the MMP-11 gene and HCC...