Article
Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene.
Oncology reports - 1 May 2008
Hata Hironobu, Kitamura Tetsuya, Higashino Fumihiro, Hida Kyoko, Yoshida Koichi, Ohiro Yoichi, Totsuka Yasunori, Kitagawa Yoshimasa, Shindoh Masanobu
Abstract excerpt
Matrix metalloproteinase (MMP) is closely involved in the degradation of extracellular matrix and confers invasive and metastatic potential to malignant tumors. MMP-2 is a type-IV collagenase secreted as a proenzyme that is activated on the surface of the tumor cell by membrane-type 1-MMP (MT1-MMP). MT1-MMP plays a critical role during tumor progression and metastasis. We investigated the expression levels of...
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