Article
Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.
Nature genetics - 1 May 2009
Palavalli Lavanya H, Prickett Todd D, Wunderlich John R, Wei Xiaomu, Burrell Allison S, Porter-Gill Patricia, Davis Sean, Wang Chenwei, Cronin Julia C, Agrawal Neena S, Lin Jimmy C, Westbroek Wendy, Hoogstraten-Miller Shelley, Molinolo Alfredo A, Fetsch Patricia, Filie Armando C, O'Connell Michael P, Banister Carolyn E, Howard Jason D, Buckhaults Phillip, Weeraratna Ashani T, Brody Lawrence C, Rosenberg Steven A, Samuels Yardena
Abstract excerpt
A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma ce...
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