A single ets-related transcription factor, E1AF, confers invasive phenotype on human cancer cells.

Article

A single ets-related transcription factor, E1AF, confers invasive phenotype on human cancer cells.

Oncogene - 18 Jan 1996

Kaya M, Yoshida K, Higashino F, Mitaka T, Ishii S, Fujinaga K

Abstract excerpt

Invasion of cancer cells is the first step of metastasis. The invasive activity is thought to be dependent on the production of matrix metalloproteinases (MMPs). The transcription regulatory regions of MMP genes often contain binding sites for Ets and AP-1 transcription factors and they mediate o...

Topics

Collagenases
Humans
Matrix Metalloproteinase 9
Neoplasm Invasiveness
Phenotype
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-ets
Transcription Factors
Transfection
Tumor Cells, Cultured

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