Article
A single ets-related transcription factor, E1AF, confers invasive phenotype on human cancer cells.
Oncogene - 18 Jan 1996
Kaya M, Yoshida K, Higashino F, Mitaka T, Ishii S, Fujinaga K
Abstract excerpt
Invasion of cancer cells is the first step of metastasis. The invasive activity is thought to be dependent on the production of matrix metalloproteinases (MMPs). The transcription regulatory regions of MMP genes often contain binding sites for Ets and AP-1 transcription factors and they mediate oncogene- and growth factor-induced transcription of the genes. We recently isolated the cDNA encoding human E1AF, a new...
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