Regulation of Matrix Metalloproteinase Genes by E2F Transcription Factors: Rb–Raf-1 Interaction as a Novel Target for Metastatic Disease

Abstract excerpt

The retinoblastoma (Rb)-E2F transcriptional regulatory pathway plays a major role in cell-cycle regulation, but its role in invasion and metastasis is less well understood. We find that many genes involved in the invasion of cancer cells, such as matrix metalloproteinases (MMP), have potential E2F-binding sites in their promoters. E2F-binding sites were predicted on all 23 human MMP gene promoters, many of which...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Peptidase Inhibition and Analysis
• Share to Protease and Inhibitor Mechanisms
• Share to Ubiquitin and proteasome pathways