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Article

E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters.

Oncology reports - 1 Apr 2005

Izumiyama Yuri, Ohiro Yoichi, Higashino Fumihiro, Yoshida Koichi, Taguchi Kazunori, Todo Satoru, Kohgo Takao, Totsuka Yasunori, Shindoh Masanobu

Abstract excerpt

E1AF is an ets-oncogene family transcription factor that has been shown to up-regulate multiple MMPs whereas MMP-2, a potent extracellular matrix degrading enzyme, is not up-regulated. We investigated the activation mechanism of MMP-2 in oral squamous cell carcinoma. Chloramphenicol acetyltransferase (CAT) assay was utilized to investigate whether E1AF is able to up-regulate membrane type-1 matrix...

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Identifiers

PMID: 15756447

Genes

CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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