Article
Association of TGF-beta1, CD14, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents.
Jornal de pediatria - 1 Jan 2000
de Faria Isabel C J, de Faria Elisangela J, Toro Adyléia A D C, Ribeiro José Dirceu, Bertuzzo Carmen Silvia
Abstract excerpt
OBJECTIVE: To verify the association of transforming growth factor-beta1(TGF-beta1) (C-509T and T869C), CD14 (C-159T), IL-4 (C-590T), IL-4R (ILe50Val) and ADAM33 (S_2) gene polymorphisms with asthma severity in a sample of patients with mild, moderate and severe persistent atopic asthma. METHODS: A clinical, laboratory, prospective study was performed in patients with persistent atopic asthma, compared to a...
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