Article
Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy.
Human genetics - 1 Jun 2007
Li Huiling, Romieu Isabelle, Wu Hao, Sienra-Monge Juan-Jose, Ramírez-Aguilar Matiana, del Río-Navarro Blanca Estela, del Lara-Sánchez Irma Carmen, Kistner Emily O, Gjessing Håkon K, London Stephanie J
Abstract excerpt
Transforming growth factor beta-1 (TGFB1) may influence asthma by modulating allergic airway inflammation and airway remodeling. The role of single nucleotide polymorphisms (SNPs) of TGFB1 in asthma remains inconclusive. We examined TGFB1 SNPs in relation to asthma risk and degree of atopy among 546 case-parent triads, consisting of asthmatics aged 4-17 years and their parents in Mexico City. Atopy to 24...
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