Article
Tensin 1 (TNS1) is a modifier gene for low body mass index (BMI) in homozygous [F508del]CFTR patients.
Physiological reports - 1 Jun 2021
Walton Nathan I, Zhang Xijun, Soltis Anthony R, Starr Joshua, Dalgard Clifton L, Wilkerson Matthew D, Conrad Douglas, Pollard Harvey B
Abstract excerpt
Cystic fibrosis (CF) is a life-limiting autosomal recessive genetic disease caused by variants in the CFTR gene, most commonly by the [F508del] variant. Although CF is a classical Mendelian disease, genetic variants in several modifier genes have been associated with variation of the clinical phenotype for pulmonary and gastrointestinal function and urogenital development. We hypothesized that whole genome...
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