Article
The influence of iron on Pseudomonas aeruginosa physiology: a regulatory link between iron and quorum sensing.
The Journal of biological chemistry - 6 Jun 2008
Oglesby Amanda G, Farrow John M, Lee Joon-Hee, Tomaras Andrew P, Greenberg E P, Pesci Everett C, Vasil Michael L
Abstract excerpt
In iron-replete environments, the Pseudomonas aeruginosa Fur (ferric uptake regulator) protein represses expression of two small regulatory RNAs encoded by prrF1 and prrF2. Here we describe the effects of iron and PrrF regulation on P. aeruginosa physiology. We show that PrrF represses genes encoding enzymes for the degradation of anthranilate (i.e. antABC), a precursor of the Pseudomonas quinolone signal (PQS)....
Topics
- Bacterial Proteins
- Gene Expression Regulation, Bacterial
- Iron
- Mutation
- Pseudomonas aeruginosa
- Quorum Sensing
- RNA, Bacterial
- RNA, Untranslated