Article
The PqrR transcriptional repressor of Pseudomonas aeruginosa transduces redox signals via an iron-containing prosthetic group.
Journal of bacteriology - 1 Nov 2009
Rungrassamee Wanilada, Ryan Kelly C, Maroney Michael J, Pomposiello Pablo J
Abstract excerpt
Inducible defenses against oxidative stress are coordinated by redox-sensitive transcription factors that transduce oxidative damage into differential gene expression. The opportunistic human pathogen Pseudomonas aeruginosa has evolved under physiological and host-derived sources of oxidative stress. Previous work showed that the pqrABC and pqrR genes of P. aeruginosa, all lacking known functions, were induced by...
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