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Article

HER2 induced EMT and tumorigenicity in breast epithelial progenitor cells is inhibited by coexpression of EGFR.

Oncogene - 11 Aug 2016

Ingthorsson S, Andersen K, Hilmarsdottir B, Maelandsmo G M, Magnusson M K, Gudjonsson T

Abstract excerpt

The members of the epidermal growth factor receptor (EGFR) kinase family are important players in breast morphogenesis and cancer. EGFR2/HER2 and EGFR expression have a prognostic value in certain subtypes of breast cancer such as HER2-amplified, basal-like and luminal type B. Many clinically approved small molecular inhibitors and monoclonal antibodies have been designed to target HER2, EGFR or both. There is,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Epithelial-Mesenchymal Transition

Share to ErbB Receptors

Share to Gene Expression Regulation, Neoplastic

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Share to Receptor, ErbB-2

Source

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Identifiers

PMID: 26686087
DOI: 10.1038/onc.2015.489
PMCID: PMC4981873

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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