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Article

Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations.

Oncogene - 2 May 2013

Furcht C M, Muñoz Rojas A R, Nihalani D, Lazzara M J

Abstract excerpt

Non-small cell lung cancer (NSCLC) cells harboring activating mutations of the epidermal growth factor receptor (EGFR) tend to display elevated activity of several survival signaling pathways. Surprisingly, these mutations also correlate with reduced phosphorylation of ERK and SHP2, a protein tyrosine phosphatase required for complete ERK activation downstream of most receptor tyrosine kinases. As ERK activity...

Topics

Adaptor Proteins, Signal Transducing
Antineoplastic Agents
Carcinoma, Non-Small-Cell Lung
Cell Membrane
ErbB Receptors
Extracellular Signal-Regulated MAP Kinases
Gefitinib
Gene Knockdown Techniques
Humans
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phosphorylation

Protein Tyrosine Phosphatase, Non-Receptor Type 11

Quinazolines

Source

Open in PubMed Open full text

Identifiers

PMID: 22777356
DOI: 10.1038/onc.2012.240
PMCID: PMC3727284

Genes

EGFR
EGF
GAB1
GRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22777356-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations.PMID 22777356Read ↗

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