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Article

Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy.

AIDS research and human retroviruses - 1 Nov 2018

Kallianpur Asha R, Gerschenson Mariana, Hulgan Todd, Kaur Harpreet, Clifford David B, Haas David W, Murdock Deborah G, McArthur Justin C, Samuels David C, Simpson David M

Abstract excerpt

Some HIV-associated complications involve mitochondrial dysfunction and may be less common in individuals with iron-loading HFE (hemochromatosis gene) variants. We evaluated HFE 845A and 187G alleles in relation to mitochondrial DNA (mtDNA) levels in peripheral blood mononuclear cells from 85 individuals with HIV infection on uninterrupted antiretroviral therapy (ART) for 15 or more consecutive weeks. Carriers of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29968489
DOI: 10.1089/AID.2018.0025
PMCID: PMC6421985

Genes

HFE

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