Article
Studies of thioguanine-resistant lymphocytes induced by in vivo irradiation of mice.
Environmental and molecular mutagenesis - 1 Jun 2008
Jones Irene M, Burkhart-Schultz Karolyn, Strout Cheryl L, Nelson David O
Abstract excerpt
The frequency of Hprt-deficient lymphocytes in mice after in vivo gamma irradiation, has been found to vary as a function of time elapsed after exposure and irradiation dose. The frequency of mutant lymphocytes in spleen was determined using an in vitro, clonogenic assay for thioguanine-resistant T-lymphocytes. Mice were exposed to single doses of 0-400 cGy from cesium-137 or to eight daily doses of 50 cGy. The...
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