Article
Charged particle mutagenesis at low dose and fluence in mouse splenic T cells.
Mutation research - 1 Jun 2016
Grygoryev Dmytro, Gauny Stacey, Lasarev Michael, Ohlrich Anna, Kronenberg Amy, Turker Mitchell S
Abstract excerpt
High-energy heavy charged particles (HZE ions) found in the deep space environment can significantly affect human health by inducing mutations and related cancers. To better understand the relation between HZE ion exposure and somatic mutation, we examined cell survival fraction, Aprt mutant frequencies, and the types of mutations detected for mouse splenic T cells exposed in vivo to graded doses of densely...
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