Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dose and dose-rate dependence of the frequency of HPRT deficient T lymphocytes in the spleen of the 137Cs gamma-irradiated mouse.

International journal of radiation biology - 1 Sept 1994

Lorenz R, Deubel W, Leuner K, Göllner T, Hochhäuser E, Hempel K

Abstract excerpt

The frequency of hypoxanthine phosphoribosyl transferase (HPRT) deficient splenic T lymphocytes was measured in the 137Cs gamma-irradiated mouse by the T cell cloning method. Doses from 0.3 to 6 Gy were applied at the dose-rates 0.5 Gy/min, 1 Gy/day and 1 Gy/week. Mutants were determined 8-10 and 30-40 weeks after the end of exposure. Radiation-induced mutant frequency (MFi) was calculated by subtracting the age...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Gamma Rays

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hypoxanthine Phosphoribosyltransferase

Share to Mice, Inbred C57BL

Share to Mutation

Share to Spleen

Share to T-Lymphocytes

Source

Identifiers

PMID: 7930834
DOI: 10.1080/09553009414551251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dose and dose-rate dependence of the frequency of HPRT deficient T lymphocytes in the spleen of the 137Cs gamma-irradiated mouse.PMID 7930834Read ↗

Studies of thioguanine-resistant lymphocytes induced by in vivo irradiation of mice.Semantic proximity Read ↗

Quantitative and qualitative effect of gamma-ray dose-rate on mutagenesis in human lymphoblastoid cells.Semantic proximity Read ↗

Dose-rate effect on the induction of HPRT mutants in human G0 lymphocytes exposed in vitro to gamma radiation.Semantic proximity Read ↗

The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation.Semantic proximity Read ↗

Radiation dose-rate effect on mutation induction in spleen and liver of gpt delta mice.Semantic proximity Read ↗

Charged particle mutagenesis at low dose and fluence in mouse splenic T cells.Semantic proximity Read ↗

Measurement of mutant frequency in T-cell receptor (TCR) gene by flow cytometry after X-irradiation on EL-4 mice lymphoma cells.Semantic proximity Read ↗

Quantification of thioguanine-resistant lymphocytes from mice irradiated in vivo.Semantic proximity Read ↗

[Age-related increase in the frequency of spontaneous and gamma-radiation-induced HPRT-mutations in murine spleen lymphocytes].Semantic proximity Read ↗

Molecular nature of mutations induced by irradiation with repeated low doses of X-rays in spleen, liver, brain and testis of lacZ-transgenic mice.Semantic proximity Read ↗

Proton-induced genetic damage in lacZ transgenic mice.Semantic proximity Read ↗

Relationships between exposure, cell loss and proliferation, and manifestation of Hprt mutant T cells following treatment of preweanling, weanling, and adult male mice with N-ethyl-N-nitrosourea.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.