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Article

The Roman high- and low-avoidance rat lines differ in the acquisition, maintenance, extinction, and reinstatement of intravenous cocaine self-administration.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2009

Fattore Liana, Piras Giovanna, Corda Maria G, Giorgi Osvaldo

Abstract excerpt

The selective breeding of Roman high- (RHA) and low-avoidance (RLA) rats for, respectively, rapid vs extremely poor acquisition of avoidant behavior in a shuttlebox has produced two phenotypes that differ in temperament traits, in mesocortical/mesolimbic dopamine system function, and in the behavioral and neurochemical responses to the acute and repeated administration of psychostimulants and opiates. The...

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Source

Identifiers

PMID: 18418365
DOI: 10.1038/npp.2008.43

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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