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Article

The HR/LR model: Further evidence as an animal model of sensation seeking.

Neuroscience and biobehavioral reviews - 1 Jul 2009

Blanchard Mathieu M, Mendelsohn Daniel, Stamp Jennifer A

Abstract excerpt

Sensation seeking is a personality trait characterized by risk-taking and the desire to experience novel stimuli. Evidence suggests that sensation seeking may increase an individual's psychological and neurobiological vulnerabilities to drug abuse. One potential animal model of human sensation seeking is high response to novelty in rats. High responders (HRs) prefer a novel environment to a familiar one and show...

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Identifiers

PMID: 19497336
DOI: 10.1016/j.neubiorev.2009.05.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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