Article
Different effects of chronic THC on the neuroadaptive response of dopamine D2/3 receptor-mediated signaling in roman high- and roman low-avoidance rats.
Synapse (New York, N.Y.) - 1 Apr 2018
Tournier Benjamin B, Dimiziani Andrea, Tsartsalis Stergios, Millet Philippe, Ginovart Nathalie
Abstract excerpt
The Roman high (RHA)- and low (RLA)-avoidance rat sublines have been identified as an addiction-prone and addiction-resistant phenotype based on their high vs. low locomotor responsiveness to novelty and high vs. low ability to develop neurochemical and behavioral sensitization to psychostimulants, respectively. Most studies though have focused on psychostimulants and little is known about the neuroadaptive...
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