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Article

A New Role for ns Polyprotein Cleavage in Sindbis Virus Replication

17 Apr 2008

Abstract excerpt

One of the distinguishing features of the alphaviruses is a sequential processing of the nonstructural polyproteins P1234 and P123. In the early stages of the infection, the complex of P123+nsP4 forms the primary replication complexes (RCs) that function in negative-strand RNA synthesis. The following processing steps make nsP1+P23+nsP4, and later nsP1+nsP2+nsP3+nsP4. The latter mature complex is active in...

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PMID: 18417571
DOI: 10.1128/jvi.02624-07

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