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Article

Regulation of the sequential processing of Semliki Forest virus replicase polyprotein.

The Journal of biological chemistry - 24 Oct 2003

Vasiljeva Lidia, Merits Andres, Golubtsov Andrey, Sizemskaja Valeria, Kääriäinen Leevi, Ahola Tero

Abstract excerpt

The replication of most positive-strand RNA viruses and retroviruses is regulated by proteolytic processing. Alphavirus replicase proteins are synthesized as a polyprotein, called P1234, which is cleaved into nsP1, nsP2, nsP3, and nsP4 by the carboxyl-terminal protease domain of nsP2. The cleavage intermediate P123+nsP4 synthesizes minus-strand copies of the viral RNA genome, whereas the completely processed...

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PMID: 12917405
DOI: 10.1074/jbc.M307481200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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