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Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice

15 Apr 2008

Abstract excerpt

Mutations in the RET gene are the primary cause of Hirschsprung disease (HSCR), or congenital intestinal aganglionosis. However, how RET malfunction leads to HSCR is not known. It has recently been shown that glial cell line-derived neurotrophic factor (GDNF) family receptor alpha1 (GFRalpha1), which binds to GDNF and activates RET, is essential for the survival of enteric neurons. In this study, we investigated...

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PMID: 18414682
DOI: 10.1172/jci34425

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Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in micePMID 18414682Read ↗

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