Article
Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes.
Proceedings of the National Academy of Sciences of the United States of America - 2 May 2006
Heanue Tiffany A, Pachnis Vassilis
Abstract excerpt
The enteric nervous system (ENS) is composed of neurons and glial cells, organized as interconnected ganglia within the gut wall, which controls peristalsis of the gut wall and secretions from its glands. The Ret receptor tyrosine kinase is expressed throughout enteric neurogenesis and is required for normal ENS development; humans with mutations in the RET locus have Hirschsprung disease (HSCR, an absence of...
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