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Article

<i>Ret</i> loss-of-function decreases neural crest progenitor proliferation and restricts developmental fate potential during enteric nervous system development

2021-12-29

Abstract excerpt

The receptor tyrosine kinase gene RET plays a critical role in the fate specification of enteric neural crest-derived cells (ENCDCs) during enteric nervous system (ENS) development. Pathogenic RET loss of function (LoF) alleles are associated with Hirschsprung disease (HSCR), which is marked by aganglionosis of the gastrointestinal (GI) tract. ENCDCs invade the developing GI tract, proliferate, migrate caudally,...

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Literature Corpus work
5b2c9991-1d5a-5bce-84b3-1f4fb7756eab
DOI
10.1101/2021.12.28.474390
Open publication

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<i>Ret</i> loss-of-function decreases neural crest progenitor proliferation and restricts developmental fate potential during enteric nervous system developmentDOI 10.1101/2021.12.28.474390
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