Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neural Precursor Death Is Central to the Pathogenesis of Intestinal Aganglionosis in<i>Ret</i>Hypomorphic Mice

14 Apr 2010

Abstract excerpt

The RET tyrosine kinase is required for the migration, proliferation, and survival of the enteric neural crest-derived cells (ENCCs) that form the enteric nervous system (ENS). Hypomorphic RET alleles cause intestinal aganglionosis [Hirschsprung disease (HSCR)], in which delayed migration and successive nonapoptotic ENCC death are considered to be major contributory factors. The significance of ENCC death in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital Anomalies and Fetal Surgery
Share to Congenital gastrointestinal and neural anomalies
Share to Intestinal Malrotation and Obstruction Disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20392943
DOI: 10.1523/jneurosci.6244-09.2010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neural Precursor Death Is Central to the Pathogenesis of Intestinal Aganglionosis in<i>Ret</i>Hypomorphic MicePMID 20392943Read ↗

Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in miceSemantic proximity Read ↗

Joint disruption of <i>Ret</i> and <i>Ednrb</i> transcription drives cell fate reversal in the Enteric Nervous System in Hirschsprung diseaseSemantic proximity Read ↗

<i>Ret</i> loss-of-function decreases neural crest progenitor proliferation and restricts developmental fate potential during enteric nervous system developmentSemantic proximity Read ↗

A Single RET Mutation in Hirschsprung Disease Induces Intestinal Aganglionosis Via a Dominant-Negative Mechanism.Semantic proximity Read ↗

Ret deficiency decreases neural crest progenitor proliferation and restricts fate potential during enteric nervous system developmentSemantic proximity Read ↗

Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype.Semantic proximity Read ↗

Enteric Nervous System: Development and Developmental Disturbances—Part 1Semantic proximity Read ↗

Hirschsprung's disease: genetic mutations in mice and men.Semantic proximity Read ↗

Ascl1 Is Required for the Development of Specific Neuronal Subtypes in the Enteric Nervous System.Semantic proximity Read ↗

Ischemia promotes hypertrophic nerve trunk formation and enteric neuron cell death in Hirschsprung’s diseaseSemantic proximity Read ↗

Balancing neural crest cell intrinsic processes with those of the microenvironment in Tcof1 haploinsufficient mice enables complete enteric nervous system formationSemantic proximity Read ↗

Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.