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Ret deficiency decreases neural crest progenitor proliferation and restricts fate potential during enteric nervous system development

16 Aug 2023

Abstract excerpt

The receptor tyrosine kinase RET plays a critical role in the fate specification of enteric neural crest–derived cells (ENCDCs) during enteric nervous system (ENS) development. RET loss of function (LoF) is associated with Hirschsprung disease (HSCR), which is marked by aganglionosis of the gastrointestinal (GI) tract. Although the major phenotypic consequences and the underlying transcriptional changes from Ret...

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PMID: 37585461
DOI: 10.1073/pnas.2211986120

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