Article
Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype.
Development (Cambridge, England) - 1 Jun 2007
Uesaka Toshihiro, Jain Sanjay, Yonemura Shigenobu, Uchiyama Yasuo, Milbrandt Jeffrey, Enomoto Hideki
Abstract excerpt
The regulation of neuronal survival and death by neurotrophic factors plays a central role in the sculpting of the nervous system, but the identity of survival signals for developing enteric neurons remains obscure. We demonstrate here that conditional ablation of GFRalpha1, the high affinity receptor for GDNF, in mice during late gestation induces rapid and widespread neuronal death in the colon, leading to...
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