Article
Prognostic significance of vascular endothelial growth factor gene polymorphisms in patients with colorectal cancer.
International journal of clinical oncology - 1 Dec 2013
Jang Moon Ju, Kim Jong Woo, Jeon Young Joo, Chong So Young, Oh Doyeun, Kim Nam Keun
Abstract excerpt
BACKGROUND: Angiogenesis plays an important role in tumor development, progression, and metastasis. Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis. However, the contribution of common VEGF polymorphisms to colorectal cancer (CRC) prognosis remains unclear. METHODS: We have genotyped four polymorphisms of VEGF (-2578C>A, -1154G>A, -634G>C, and 936C>T) in 350 CRC cases from the Korean...
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