Article
Association between bevacizumab-related hypertension and vascular endothelial growth factor (VEGF) gene polymorphisms in Japanese patients with metastatic colorectal cancer.
Cancer chemotherapy and pharmacology - 1 Feb 2013
Morita Sachi, Uehara Keisuke, Nakayama Goro, Shibata Takashi, Oguri Tomoyo, Inada-Inoue Megumi, Shimokata Tomoya, Sugishita Mihoko, Mitsuma Ayako, Ando Yuichi
Abstract excerpt
PURPOSE: Bevacizumab, a monoclonal antibody that binds to VEGF, has a well-known toxic effect of hypertension. We studied possible associations between bevacizumab-related hypertension and gene polymorphisms to assure safer cancer therapy. METHODS: We retrospectively studied 60 Japanese patients with metastatic colorectal cancer who had received bevacizumab-based chemotherapy. Genotypes were determined for five...
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