A microRNA binding site polymorphism in the 3' UTR region of VEGF-A gene modifies colorectal cancer risk based on ethnicity: a meta-analysis.

doi:10.1186/s43046-022-00118-3

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Article

A microRNA binding site polymorphism in the 3' UTR region of VEGF-A gene modifies colorectal cancer risk based on ethnicity: a meta-analysis.

Journal of the Egyptian National Cancer Institute - 25 Apr 2022

Kontham Sai Sushmitha, Walter Charles Emmanuel Jebaraj, Shankaran Zioni Sangeetha, Ramanathan Arvind, Karuppasamy Nirmala, Johnson Thanka

Abstract excerpt

BACKGROUND: Vascular endothelial growth factor A (VEGF-A) plays an integral role in angiogenesis by contributing to growth, development, and metastasis of solid tumors. Recently, a single-nucleotide polymorphism +936C/T located in the VEGF-A 3' untranslated region (UTR) facilitated the susceptibi...

Topics

3' Untranslated Regions
Binding Sites
Case-Control Studies
Colorectal Neoplasms
Ethnicity
Genetic Predisposition to Disease
Humans
MicroRNAs
Polymorphism, Single Nucleotide
Risk
Vascular Endothelial Growth Factor A

Source

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Identifiers

PMID: 35462603
DOI: 10.1186/s43046-022-00118-3
PMCID: PMC13314259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-35462603-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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