Article
MiRSNPs or MiR-polymorphisms, new players in microRNA mediated regulation of the cell: Introducing microRNA pharmacogenomics.
Cell cycle (Georgetown, Tex.) - 1 Apr 2008
Mishra Prasun J, Mishra Pravin J, Banerjee Debabrata, Bertino Joseph R
Abstract excerpt
MicroRNAs are evolutionarily conserved small non-coding RNAs known to inhibit the translation of proteins by binding to the target transcript in the 3' untranslated region. Functional polymorphisms in 3' UTRs of several genes have been reported to be associated with diseases by affecting gene expression. The mechanism by which these polymorphisms affect gene expression and induce variability in a cell is not well...
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