Article
An artifact derived from a pseudogene led to the discovery of microRNA binding site polymorphism in the 3'-untranslated region of the human dihydrofolate reductase gene.
Drug metabolism and pharmacokinetics - 1 Jan 2012
Hayashi Hideki, Tazoe Yui, Horino Masato, Fujimaki-Katoh Chihiro, Tsuboi Seiji, Matsuyama Taiji, Kosuge Kazuhiro, Yamada Hiroshi, Tsuji Daiki, Inoue Kazuyuki, Itoh Kunihiko
Abstract excerpt
A novel single-nucleotide polymorphism (SNP) in the 3'-untranslated region of the human dihydrofolate reductase (DHFR) gene with enhanced expression was identified in 2001. In 2007, it was reported that this SNP, DHFR C829T, was located close to a microRNA binding site and contributed to the stability of mRNA. Many researchers have analyzed this SNP in several races including Asians and Caucasians. However, the...
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