Article
Polymorphisms in microRNA targets: a gold mine for molecular epidemiology.
Carcinogenesis - 1 Jul 2008
Chen Kexin, Song Fengju, Calin George A, Wei Qingyi, Hao Xishan, Zhang Wei
Abstract excerpt
MicroRNAs are non-coding small RNAs that regulate gene expression by Watson-Crick base pairing to target messenger RNA (mRNA). They are involved in most biological and pathological processes, including tumorigenesis. The binding of microRNA to mRNA is critical for regulating the mRNA level and protein expression. However, this binding can be affected by single-nucleotide polymorphisms that can reside in the...
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