Article
Bioinformatics prioritization of SNPs perturbing microRNA regulation of hematological malignancy-implicated genes.
Genomics - 1 Dec 2015
Ghaedi Hamid, Bastami Milad, Zare-Abdollahi Davood, Alipoor Behnam, Movafagh Abolfazl, Mirfakhraie Reza, Omrani Mir Davood, Masotti Andrea
Abstract excerpt
The contribution of microRNAs (miRNAs) to cancer has been extensively investigated and it became obvious that a strict regulation of miRNA-mRNA regulatory network is crucial for safeguarding cell health. Apart from the direct impact of miRNA dysregulation in cancer pathogenesis, genetic variations in miRNAs are likely to disrupt miRNA-target interaction. Indeed, many evidences suggested that SNPs within miRNA...
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