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Article

Gene Promoter Hypermethylation Detected in Sputum Predicts FEV1 Decline and All-Cause Mortality in Smokers.

American journal of respiratory and critical care medicine - 15 Jul 2018

Leng Shuguang, Diergaarde Brenda, Picchi Maria A, Wilson David O, Gilliland Frank D, Yuan Jian-Min, Siegfried Jill M, Belinsky Steven A

Abstract excerpt

RATIONALE: Gene promoter hypermethylation detected in sputum assesses the extent of field cancerization and predicts lung cancer (LC) risk in ever-smokers. A rapid decline of FEV1 is a major driver for development of airway obstruction. OBJECTIVES: To assess the effects of methylation of 12 genes on FEV1 decline and of FEV1 decline on subsequent LC incidence using two independent, longitudinal cohorts (i.e., LSC...

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Identifiers

PMID: 29437466
DOI: 10.1164/rccm.201708-1659OC
PMCID: PMC6058990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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