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Article

Neutrophil-derived leukotriene B4 is required for inflammatory arthritis.

The Journal of experimental medicine - 17 Apr 2006

Chen Mei, Lam Bing K, Kanaoka Yoshihide, Nigrovic Peter A, Audoly Laurent P, Austen K Frank, Lee David M

Abstract excerpt

Neutrophils serve as a vanguard of the acute innate immune response to invading pathogens. Neutrophils are also abundant at sites of autoimmune inflammation, such as the rheumatoid joint, although their pathophysiologic role is incompletely defined and relevant effector functions remain obscure. Using genetic and pharmacologic approaches in the K/BxN serum transfer model of arthritis, we find that...

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Identifiers

PMID: 16567388
DOI: 10.1084/jem.20052371
PMCID: PMC2118292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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