Article
Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood.
The British journal of dermatology - 1 Jun 2008
Arshad S H, Karmaus W, Kurukulaaratchy R, Sadeghnejad A, Huebner M, Ewart S
Abstract excerpt
BACKGROUND: Atopic eczema is characterized by Th2-dominant immunity with the cytokine interleukin 13 and the transcription factor GATA binding protein 3 playing a critical role. OBJECTIVES: We assessed the association of polymorphisms in the IL13 and GATA3 genes with childhood eczema. METHODS: A birth cohort (n = 1456) was established on the Isle of Wight in 1989 and followed at the ages of 1 (n = 1167), 2 (n =...
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