Article
The gene encoding interleukin-13: a susceptibility locus for asthma and related traits.
Respiratory research - 1 Jan 2000
Wills-Karp M
Abstract excerpt
Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma. Recently, the Th2 cytokine interleukin-13 has been shown to be a critical mediator of the asthma phenotype in murine models. In this commentary we discuss several recent...
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