Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs.

Pharmacogenetics and genomics - 1 May 2008

Hung Chin-Chuan, Chen Chih-Chuan, Lin Chun-Jung, Liou Horng-Huei

Abstract excerpt

OBJECTIVE: The ABCB1 haplotype combinations have been demonstrated to be associated with epilepsy treatment outcomes. The aim of this study is to investigate whether ABCB1 haplotype combinations would affect P-glycoprotein (Pgp) function and impact the clinical responses of antiepileptic drugs (AEDs). METHODS AND RESULTS: Transport of substrate rhodamine 123 and calcein-AM by human Pgp carrying 12 haplotype...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticonvulsants
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Share to Drug Resistance

Share to Epilepsy

Share to Fluoresceins

Share to Fluorescent Dyes

Share to Rhodamine 123

Source

Identifiers

PMID: 18408562
DOI: 10.1097/FPC.0b013e3282f85e36

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs.PMID 18408562Read ↗

Association of ABCB1 gene polymorphisms and their haplotypes with response to antiepileptic drugs: a systematic review and meta-analysis.Semantic proximity Read ↗

Polymorphisms Affecting the Response to Novel Antiepileptic Drugs.Semantic proximity Read ↗

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature.Semantic proximity Read ↗

Determination of ABCB1 polymorphisms and haplotypes frequencies in a French population.Semantic proximity Read ↗

Polymorphisms in the Drug Transporter Gene ABCB1 Are Associated with Drug Response in Saudi Epileptic Pediatric PatientsSemantic proximity Read ↗

ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research.Semantic proximity Read ↗

The roles of variants in human multidrug resistance (MDR1) gene and their haplotypes on antiepileptic drugs response: a meta-analysis of 57 studies.Semantic proximity Read ↗

Ethnicity-related polymorphisms and haplotypes in the human ABCB1 gene.Semantic proximity Read ↗

Association between lamotrigine concentrations and ABCB1 polymorphisms in patients with epilepsy.Semantic proximity Read ↗

Variation and evolution of the ABC transporter genes ABCB1, ABCC1, ABCG2, ABCG5 and ABCG8: implication for pharmacogenetics and disease.Semantic proximity Read ↗

Complex haplotypic effects of the ABCB1 gene on epilepsy treatment response.Semantic proximity Read ↗

Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2: therapeutic implications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.