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Mutations in Troponin that cause HCM, DCM AND RCM: what can we learn about thin filament function?

Journal of molecular and cellular cardiology - 1 May 2010

Willott Ruth H, Gomes Aldrin V, Chang Audrey N, Parvatiyar Michelle S, Pinto Jose Renato, Potter James D

Abstract excerpt

Troponin (Tn) is a critical regulator of muscle contraction in cardiac muscle. Mutations in Tn subunits are associated with hypertrophic, dilated and restrictive cardiomyopathies. Improved diagnosis of cardiomyopathies as well as intensive investigation of new mouse cardiomyopathy models has significantly enhanced this field of research. Recent investigations have showed that the physiological effects of Tn...

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Identifiers

PMID: 19914256
DOI: 10.1016/j.yjmcc.2009.10.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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