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Article

Gene correction and overexpression of TNNI3 improve impaired relaxation in engineered heart tissue model of pediatric restrictive cardiomyopathy.

Development, growth & differentiation - 1 Feb 2024

Hasegawa Moyu, Miki Kenji, Kawamura Takuji, Takei Sasozaki Ikue, Higashiyama Yuki, Tsuchida Masaru, Kashino Kunio, Taira Masaki, Ito Emiko, Takeda Maki, Ishida Hidekazu, Higo Shuichiro, Sakata Yasushi, Miyagawa Shigeru

Abstract excerpt

Research on cardiomyopathy models using engineered heart tissue (EHT) created from disease-specific induced pluripotent stem cells (iPSCs) is advancing rapidly. However, the study of restrictive cardiomyopathy (RCM), a rare and intractable cardiomyopathy, remains at the experimental stage because there is currently no established method to replicate the hallmark phenotype of RCM, particularly diastolic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38193576
DOI: 10.1111/dgd.12909
PMCID: PMC11457505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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