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Article

Structure and stability changes of human IgG1 Fc as a consequence of methionine oxidation.

Biochemistry - 6 May 2008

Liu Dingjiang, Ren Da, Huang Holly, Dankberg Jane, Rosenfeld Robert, Cocco Melanie J, Li Luke, Brems David N, Remmele Richard L

Abstract excerpt

The Fc region has two highly conserved methionine residues, Met 33 (C(H)3 domain) and Met 209 (C(H)3 domain), which are important for the Fc's structure and biological function. To understand the effect of methionine oxidation on the structure and stability of the human IgG1 Fc expressed in Escherichia coli, we have characterized the fully oxidized Fc using biophysical (DSC, CD, and NMR) and bioanalytical (SEC...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18407665
DOI: 10.1021/bi702238b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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